diff --git a/cocos/2d/CCNode.cpp b/cocos/2d/CCNode.cpp
index dc8c0f39e5..b31d4b916f 100644
--- a/cocos/2d/CCNode.cpp
+++ b/cocos/2d/CCNode.cpp
@@ -1180,12 +1180,11 @@ uint32_t Node::processParentFlags(const Mat4& parentTransform, uint32_t parentFl
         }
     }
 
-    //remove this two line given that isVisitableByVisitingCamera should not affect the calculation of transform given that we are visiting scene
-    //without involving view and projection matrix.
-    
-//    if (!isVisitableByVisitingCamera())
-//        return parentFlags;
-    
+    // Fixes Github issue #16100. Basically when having two cameras, one camera might set as dirty the
+    // node that is not visited by it, and might affect certain calculations. Besides, it is faster to do this.
+    if (!isVisitableByVisitingCamera())
+        return parentFlags;
+
     uint32_t flags = parentFlags;
     flags |= (_transformUpdated ? FLAGS_TRANSFORM_DIRTY : 0);
     flags |= (_contentSizeDirty ? FLAGS_CONTENT_SIZE_DIRTY : 0);
diff --git a/cocos/2d/CCSprite.cpp b/cocos/2d/CCSprite.cpp
index 810b35cb3d..72dcde3e6e 100644
--- a/cocos/2d/CCSprite.cpp
+++ b/cocos/2d/CCSprite.cpp
@@ -651,14 +651,15 @@ void Sprite::draw(Renderer *renderer, const Mat4 &transform, uint32_t flags)
     }
     
 #if CC_USE_CULLING
-    // Don't do calculate the culling if the transform was not updated
+    // Don't calculate the culling if the transform was not updated
     auto visitingCamera = Camera::getVisitingCamera();
     auto defaultCamera = Camera::getDefaultCamera();
     if (visitingCamera == defaultCamera) {
-        _insideBounds = ((flags & FLAGS_TRANSFORM_DIRTY)|| visitingCamera->isViewProjectionUpdated()) ? renderer->checkVisibility(transform, _contentSize) : _insideBounds;
+        _insideBounds = ((flags & FLAGS_TRANSFORM_DIRTY) || visitingCamera->isViewProjectionUpdated()) ? renderer->checkVisibility(transform, _contentSize) : _insideBounds;
     }
     else
     {
+        // XXX: this always return true since
         _insideBounds = renderer->checkVisibility(transform, _contentSize);
     }
 
diff --git a/tests/cpp-tests/Classes/NodeTest/NodeTest.cpp b/tests/cpp-tests/Classes/NodeTest/NodeTest.cpp
index deca07c968..ed92478a67 100644
--- a/tests/cpp-tests/Classes/NodeTest/NodeTest.cpp
+++ b/tests/cpp-tests/Classes/NodeTest/NodeTest.cpp
@@ -71,6 +71,7 @@ CocosNodeTests::CocosNodeTests()
     ADD_TEST_CASE(NodeNormalizedPositionTest2);
     ADD_TEST_CASE(NodeNormalizedPositionBugTest);
     ADD_TEST_CASE(NodeNameTest);
+    ADD_TEST_CASE(Issue16100Test);
 }
 
 TestCocosNodeDemo::TestCocosNodeDemo(void)
@@ -1445,3 +1446,69 @@ void NodeNameTest::test(float dt)
     auto findChildren = utils::findChildren(*parent, "node");
     CCAssert(findChildren.size() == 50, "");
 }
+
+//------------------------------------------------------------------
+//
+// Issue16100Test
+//
+//------------------------------------------------------------------
+void Issue16100Test::onEnter()
+{
+    TestCocosNodeDemo::onEnter();
+
+    // create user camera
+    auto s = Director::getInstance()->getWinSize();
+
+    auto delay = DelayTime::create(0.1f);
+    auto f = CallFunc::create([this, s]()
+    {
+        auto camera = Camera::createOrthographic(s.width * 2, s.height * 2, -1024, 1024);
+        camera->setCameraFlag(CameraFlag::USER1);
+        addChild(camera);
+    });
+    this->runAction(Sequence::createWithTwoActions(delay, f));
+
+    // grossini using default camera
+    auto sprite = Sprite::create("Images/grossini.png");
+    this->addChild(sprite);
+
+    sprite->setPosition(-200,s.height/3);
+    auto moveby = MoveBy::create(2, Vec2(400,0));
+    auto movebyback = moveby->reverse();
+    auto seq = Sequence::create(moveby, movebyback, nullptr);
+    auto forever = RepeatForever::create(seq);
+
+    sprite->runAction(forever);
+
+    sprite->setCameraMask((int)CameraFlag::DEFAULT);
+
+
+    // grossini's sister using user camera
+    auto sister = Sprite::create("Images/grossinis_sister1.png");
+    this->addChild(sister);
+
+    sister->setPosition(-200,s.height*2/3);
+    auto moveby1 = MoveBy::create(2, Vec2(400,0));
+    auto movebyback1 = moveby1->reverse();
+    auto seq1 = Sequence::create(moveby1, movebyback1, nullptr);
+    auto forever1 = RepeatForever::create(seq1);
+
+    sister->runAction(forever1);
+    sister->setCameraMask((int)CameraFlag::USER1);
+}
+
+void Issue16100Test::onExit()
+{
+    TestCocosNodeDemo::onExit();
+}
+
+std::string Issue16100Test::title() const
+{
+    return "Issue 16100";
+}
+
+std::string Issue16100Test::subtitle() const
+{
+    return "Sprite should appear on the screen";
+}
+
diff --git a/tests/cpp-tests/Classes/NodeTest/NodeTest.h b/tests/cpp-tests/Classes/NodeTest/NodeTest.h
index 7124f7a708..2e27ef14a5 100644
--- a/tests/cpp-tests/Classes/NodeTest/NodeTest.h
+++ b/tests/cpp-tests/Classes/NodeTest/NodeTest.h
@@ -330,4 +330,15 @@ public:
     void test(float dt);
 };
 
+class Issue16100Test : public TestCocosNodeDemo
+{
+public:
+    CREATE_FUNC(Issue16100Test);
+    virtual std::string title() const override;
+    virtual std::string subtitle() const override;
+
+    virtual void onEnter() override;
+    virtual void onExit() override;
+};
+
 #endif