diff --git a/core/platform/desktop/CCGLViewImpl-desktop.cpp b/core/platform/desktop/CCGLViewImpl-desktop.cpp
index 9076864f05..15b3a2cbed 100644
--- a/core/platform/desktop/CCGLViewImpl-desktop.cpp
+++ b/core/platform/desktop/CCGLViewImpl-desktop.cpp
@@ -489,7 +489,7 @@ bool GLViewImpl::initWithRect(std::string_view viewName, Rect rect, float frameZ
     }
 
     // Will cause OpenGL error 0x0500 when use ANGLE-GLES on desktop
-#if defined(AX_USE_GL)
+#if !defined(AX_USE_GLES)
     // Enable point size by default.
 #    if defined(GL_VERSION_2_0)
     glEnable(GL_VERTEX_PROGRAM_POINT_SIZE);
@@ -1198,7 +1198,7 @@ bool GLViewImpl::loadGL()
 
     // glad: load all OpenGL function pointers
     // ---------------------------------------
-#   if defined(AX_USE_GL)
+#   if !defined(AX_USE_GLES)
     if (!gladLoadGL(glfwGetProcAddress))
     {
         log("glad: Failed to Load GL");
diff --git a/core/renderer/backend/opengl/CommandBufferGL.cpp b/core/renderer/backend/opengl/CommandBufferGL.cpp
index 9791e1dbad..8650bb56d5 100644
--- a/core/renderer/backend/opengl/CommandBufferGL.cpp
+++ b/core/renderer/backend/opengl/CommandBufferGL.cpp
@@ -214,13 +214,13 @@ void CommandBufferGL::setProgramState(ProgramState* programState)
 void CommandBufferGL::drawArrays(PrimitiveType primitiveType, std::size_t start, std::size_t count, bool wireframe)
 {
     prepareDrawing();
-#ifdef AX_USE_GL  // glPolygonMode is only supported in Desktop OpenGL
+#ifndef AX_USE_GLES  // glPolygonMode is only supported in Desktop OpenGL
     if (wireframe) glPolygonMode(GL_FRONT_AND_BACK, GL_LINE);
 #else
     if (wireframe) primitiveType = PrimitiveType::LINE;
 #endif
     glDrawArrays(UtilsGL::toGLPrimitiveType(primitiveType), start, count);
-#ifdef AX_USE_GL  // glPolygonMode is only supported in Desktop OpenGL
+#ifndef AX_USE_GLES  // glPolygonMode is only supported in Desktop OpenGL
     if (wireframe) glPolygonMode(GL_FRONT_AND_BACK, GL_FILL);
 #endif
     cleanResources();
@@ -233,7 +233,7 @@ void CommandBufferGL::drawElements(PrimitiveType primitiveType,
                                    bool wireframe)
 {
     prepareDrawing();
-#ifdef AX_USE_GL  // glPolygonMode is only supported in Desktop OpenGL
+#ifndef AX_USE_GLES  // glPolygonMode is only supported in Desktop OpenGL
     if (wireframe) glPolygonMode(GL_FRONT_AND_BACK, GL_LINE);
 #else
     if (wireframe) primitiveType = PrimitiveType::LINE;
@@ -242,7 +242,7 @@ void CommandBufferGL::drawElements(PrimitiveType primitiveType,
     glDrawElements(UtilsGL::toGLPrimitiveType(primitiveType), count, UtilsGL::toGLIndexType(indexType),
                    (GLvoid*)offset);
     CHECK_GL_ERROR_DEBUG();
-#ifdef AX_USE_GL  // glPolygonMode is only supported in Desktop OpenGL
+#ifndef AX_USE_GLES  // glPolygonMode is only supported in Desktop OpenGL
     if (wireframe) glPolygonMode(GL_FRONT_AND_BACK, GL_FILL);
 #endif
     cleanResources();
diff --git a/core/renderer/backend/opengl/DeviceInfoGL.cpp b/core/renderer/backend/opengl/DeviceInfoGL.cpp
index f6be545686..2324fd1114 100644
--- a/core/renderer/backend/opengl/DeviceInfoGL.cpp
+++ b/core/renderer/backend/opengl/DeviceInfoGL.cpp
@@ -68,7 +68,7 @@ static bool checkReallySupportsASTC()
                            astctexels);
 
     auto error = glGetError();
-#if defined(AX_USE_GL)
+#if !defined(AX_USE_GLES)
     if (!error && glGetTexImage)
     {
         // read pixel RGB: should be: 255, 128, 0
diff --git a/extensions/ImGui/ImGuiPresenter.cpp b/extensions/ImGui/ImGuiPresenter.cpp
index aef16b139c..20dfbec868 100644
--- a/extensions/ImGui/ImGuiPresenter.cpp
+++ b/extensions/ImGui/ImGuiPresenter.cpp
@@ -8,7 +8,7 @@
 #include "imgui_internal.h"
 
 // TODO: mac metal
-#if (defined(AX_USE_GL) || defined(AX_USE_GLES))
+#if defined(AX_USE_GL)
 #    define AX_IMGUI_ENABLE_MULTI_VIEWPORT 1
 #else
 #    define AX_IMGUI_ENABLE_MULTI_VIEWPORT 0